Transcriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response.
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ABSTRACT:
SUBMITTER: Cozzolino M
PROVIDER: S-EPMC9156844 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
Transcriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response.
Cozzolino Mauro M Herraiz Sonia S Titus Shiny S Roberts Leah L Romeu Monica M Peinado Irene I Scott Richard T RT Pellicer Antonio A Seli Emre E
Human reproduction (Oxford, England) 20220501 6
<h4>Study question</h4>Are transcriptomic profiles altered in ovarian granulosa cells (GCs) and peripheral blood mononuclear cells (PBMNCs) of women with polycystic ovary syndrome (PCOS) compared to young poor responders (YPR) and women with normal response to ovarian stimulation?<h4>Summary answer</h4>RNA expression profiles in ovarian GCs and PBMNCs were significantly altered in patients with PCOS compared with normoresponder controls (CONT) and YPR.<h4>What is known already</h4>PCOS is charac ...[more]
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