Interaction between cigarette smoking and genetic polymorphisms on the associations with age of natural menopause and reproductive lifespan: the Singapore Chinese Health Study.

ABSTRACT:

Study question

Are there genetic variants that interact with smoking to reduce reproductive lifespan in East-Asian women?

Summary answer

Our study corroborates several recently identified genetic loci associated with reproductive lifespan and highlights specific genetic predispositions that may interact with smoking status to adversely affect reproductive lifespan in East-Asian women.

What is known already

Epidemiological data as well as evaluations on genetic predisposition to smoke indicate on the importance of smoking in adverse effects on reproductive lifespan in women. However, there are no previous smoking and gene interaction studies for reproductive traits in East-Asian women.

Study design, size, duration

This population-based prospective cohort study c

SUBMITTER: Huang Z 

PROVIDER: S-EPMC9156846 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature