Feasibility of biology-guided radiotherapy using PSMA-PET to boost to dominant intraprostatic tumour.

ABSTRACT:

Background

Biology-guided radiotherapy (BgRT) delivers dose to tumours triggered from positron emission tomography (PET) detection. Prostate specific membrane antigen (PSMA) PET uptake is abundant in the dominant intraprostatic lesion (DIL). This study investigates the feasibility of BgRT to PSMA-avid subvolume in the prostate region.

Methods

Patients enrolled in the prospective randomized trial ProPSMA at our institution were included (ID: ANZCTR12617000005358). Gross tumour volumes (GTVs) were delineated on the PET component of a PET/CT scan from a standardized uptake value (SUV) threshold technique. Suitability for BgRT requires a strong signal-to-background ratio with a surrounding tissue free of significant PSMA uptake. The signal-to-background ratio was quantified from

SUBMITTER: Gaudreault M 

PROVIDER: S-EPMC9156937 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature