ABO genotype alters the gut microbiota by regulating GalNAc levels in pigs.

ABSTRACT: The composition of the intestinal microbiome varies considerably between individuals and is correlated with health¹. Understanding the extent to which, and how, host genetics contributes to this variation is essential yet has proved to be difficult, as few associations have been replicated, particularly in humans². Here we study the effect of host genotype on the composition of the intestinal microbiota in a large mosaic pig population. We show that, under conditions of exacerbated genetic diversity and environmental uniformity, microbiota composition and the abundance of specific taxa are heritable. We map a quantitative trait locus affecting the abundance of Erysipelotrichaceae species and show that it is caused by a 2.3 kb deletion in the gene encoding N-acetyl-gal

SUBMITTER: Yang H 

PROVIDER: S-EPMC9157047 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature