The ectodysplasin-A receptor is a candidate gene for lateral plate number variation in stickleback fish.

ABSTRACT: Variation in lateral plating in stickleback fish represents a classical example of rapid and parallel adaptation in morphology. The underlying genetic architecture involves polymorphism at the ectodysplasin-A gene (EDA). However, lateral plate number is influenced by additional loci that remain poorly characterized. Here, we search for such loci by performing genome-wide differentiation mapping based on pooled whole-genome sequence data from a European stickleback population variable in the extent of lateral plating, while tightly controlling for the phenotypic effect of EDA. This suggests a new candidate locus, the EDA receptor gene (EDAR), for which additional support is obtained by individual-level targeted Sanger sequencing and by comparing allele frequencies among natural populations.

SUBMITTER: Laurentino TG 

PROVIDER: S-EPMC9157104 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature