Histopathology, salivary flow and ultrasonography of the parotid gland: three complementary measurements in primary Sjogren's syndrome.

ABSTRACT:

Objective

The involvement of salivary glands in primary SS (pSS) can be assessed in different ways: histopathology, salivary flow and ultrasonography. To understand the relative value of these different approaches, it is crucial to understand the relationship between them. As we routinely perform these three modalities in the parotid gland for disease evaluation, our aim was to investigate the construct validity between these modalities in one and the same gland.

Methods

Consecutive sicca patients underwent a multidisciplinary diagnostic workup including parotid gland biopsy, collection of parotid gland-specific saliva and parotid gland ultrasonography. Patients who were classified as pSS according to the ACR-EULAR criteria were included. Construct validity was assessed usin

SUBMITTER: Mossel E 

PROVIDER: S-EPMC9157128 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature