Identification of novel split-GAL4 drivers for the characterization of enteroendocrine cells in the Drosophila melanogaster midgut.

ABSTRACT: The Drosophila melanogaster midgut is commonly studied as a model epithelial tissue for many reasons, one of which is the presence of a diverse population of secretory cells called enteroendocrine cells. Subpopulations of these cells secrete various combinations of peptide hormones which have systemic effects on the organism. Many of these hormones are also produced in the Drosophila brain. The split-GAL4 system has been useful for identifying and manipulating discrete groups of cells, but previously characterized split-GAL4 drivers have not driven expression in high proportions of enteroendocrine cells. In this study, we screened candidate split-GAL4 drivers for enteroendocrine cell expression using known reference drivers for this cell type and discovered a new split-GAL4 driver pair tha

SUBMITTER: Holsopple JM 

PROVIDER: S-EPMC9157172 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature