Polygenic risk for ADHD and ASD and their relation with cognitive measures in school children.

ABSTRACT:

Background

Attention deficit and hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are child-onset neurodevelopmental disorders frequently accompanied by cognitive difficulties. In the current study, we aim to examine the genetic overlap between ADHD and ASD and cognitive measures of working memory (WM) and attention performance among schoolchildren using a polygenic risk approach.

Methods

A total of 1667 children from a population-based cohort aged 7-11 years with data available on genetics and cognition were included in the analyses. Polygenic risk scores (PRS) were calculated for ADHD and ASD using results from the largest GWAS to date (N = 55 374 and N = 46 351, respectively). The cognitive outcomes included verbal and numerical WM and the standard error o

SUBMITTER: Aguilar-Lacasana S 

PROVIDER: S-EPMC9157306 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature