Depression and Anxiety in the Epilepsies: from Bench to Bedside.

ABSTRACT:

Purpose of review

Depression and anxiety substantially contribute to interictal disability in patients with epilepsy (PWE). This review summarizes current studies that shed light on mechanisms of comorbidity.

Recent findings

Mounting epidemiological data implicate shared risk factors for anxiety/depression and seizure propensity, but these remain largely elusive and probably vary by epilepsy type. Within PWE, these symptoms appear to be associated with unique genetic, neuropathological, and connectivity profiles. Temporal lobe epilepsy has received enormous emphasis particularly in preclinical studies of comorbidity, where candidate neurobiological mechanisms underlying bidirectionality have been tested without psychopharmacological confounds. Depression and anxiety in epile

SUBMITTER: Krishnan V 

PROVIDER: S-EPMC9157472 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature