Molecular signature of cardiac remodeling associated with Polymerase Gamma mutation.

ABSTRACT:

Aims

Metabolic function/dysfunction is central to aging biology. This is well illustrated by the Polymerase Gamma (POLG) mutant mouse where a key residue of the mitochondrial DNA polymerase is mutated (D257A), causing loss of mitochondrial DNA stability and dramatically accelerated aging processes. Given known cardiac phenotypes in the POLG mutant, we sought to characterize the course of cardiac dysfunction in the POLG mutant to guide future intervention studies.

Materials and methods

Cardiac echocardiography and terminal hemodynamic analyses were used to define the course of dysfunction in the right and left cardiac ventricles in the POLG mutant. We also conducted RNA-seq analysis on cardiac right ventricles to identify mechanisms engaged by severe metabolic dysfunction and

SUBMITTER: Gorr MW 

PROVIDER: S-EPMC9158136 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature