The effect of gum Arabic supplementation on cathelicidin expression in monocyte derived macrophages in mice.

ABSTRACT:

Background

Antimicrobial peptides (AMPs) are important effectors of the innate defense system. Cathelicidins, (CRAMP in mouse/rat, LL-37 in human) is one of the two major classes of AMPs in humans. The upregulation of LL-37 synthesis is a novel non-antibiotic approach to prevent or treat infectious diseases. Butyrate was found to induce Cathelicidin expression. Gum Arabic (GA), an exudate from Acacia senegaltree, is known for its prebiotic effects. Fermentation of GA by colonic bacteria increases serum butyrate concentrations. This study was conducted to investigate if GA supplementation can increase Cathelicidin expression in macrophages.

Methods

The study was an in-vivo experiment in mice. Thirty mice were randomly divided into three groups, ten mice per group. The two int

SUBMITTER: Siednamohammeddeen N 

PROVIDER: S-EPMC9158159 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature