Altered transcriptional responses in the lungs of aged mice after influenza infection.

ABSTRACT:

Background

Influenza causes a serious infection in older individuals who are at the highest risk for mortality from this virus. Changes in the immune system with age are well known. This study used transcriptomic analysis to evaluate how aging specifically affects the functional host response to influenza in the lung. Adult (12-16 weeks) and aged (72-76 weeks) mice were infected with influenza and lungs were processed for RNA analysis.

Results

Older mice demonstrated a delayed anti-viral response on the level of transcription compared to adults, similar to the immunologic responses measured in prior work. The transcriptional differences, however, were evident days before observable differences in the protein responses described previously. The transcriptome response to influ

SUBMITTER: Hernandez AM 

PROVIDER: S-EPMC9158162 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature