Plasma repressor element 1-silencing transcription factor levels are decreased in patients with Alzheimer's disease.

ABSTRACT:

Background

Repressor element 1-silencing transcription (REST)/neuron-restrictive silencer factor is considered a new therapeutic target for neurodegenerative disorders such as Alzheimer's disease (AD). However, the relationship between AD and REST remains unclear. This study aimed to 1) examine plasma REST levels and REST gene levels in AD patients and 2) further explore the pathological relationships between REST protein levels and cognitive decline in clinical conditions, including medial temporal lobe atrophy.

Methods

Participants (n = 252, mean age 68.95 ± 8.78 years) were recruited in Beijing, China, and then divided into a normal cognition (NC) group (n = 89), an amnestic mild cognitive impairment (aMCI) group (n = 79), and an AD dementia group (n = 84) according to di

SUBMITTER: Wei M 

PROVIDER: S-EPMC9158200 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature