Genome-wide analyses reveal a strong association between LEPR gene variants and body fat reserves in ewes.

ABSTRACT:

Background

Among the adaptive capacities of animals, the management of energetic body reserves (BR) through the BR mobilization and accretion processes (BR dynamics, BRD) has become an increasingly valuable attribute for livestock sustainability, allowing animals to cope with more variable environments. BRD has previously been reported to be heritable in ruminants. In the present work, we conducted genome-wide studies (GWAS) in sheep to determine genetic variants associated with BRD. BR (i.e. levels) and BRD (i.e. changes over time) were obtained through body condition score measurements at eight physiological stages throughout each productive cycle in Romane ewes (n = 1034) and were used as phenotypes for GWAS. After quality controls and imputation, 48,593 single nucleotide polymo

SUBMITTER: Mace T 

PROVIDER: S-EPMC9158286 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature