Lower functional hippocampal connectivity in healthy adults is jointly associated with higher levels of leptin and insulin resistance.

ABSTRACT:

Background

Metabolic dysregulation is currently considered a major risk factor for hippocampal pathology. The aim of the present study was to characterize the influence of key metabolic drivers on functional connectivity of the hippocampus in healthy adults.

Methods

Insulin resistance was directly quantified by measuring steady-state plasma glucose (SSPG) concentration during the insulin suppression test and fasting levels of insulin, glucose, leptin, and cortisol, and measurements of body mass index and waist circumference were obtained in a sample of healthy cognitively intact adults (n = 104). Resting-state neuroimaging data were also acquired for the quantification of hippocampal functional cohesiveness and integration with the major resting-state networks (RSNs). Data-d

SUBMITTER: Haas SS 

PROVIDER: S-EPMC9158395 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature