Modeling Calcium Signaling in S. cerevisiae Highlights the Role and Regulation of the Calmodulin-Calcineurin Pathway in Response to Hypotonic Shock.

ABSTRACT: Calcium homeostasis and signaling processes in Saccharomyces cerevisiae, as well as in any eukaryotic organism, depend on various transporters and channels located on both the plasma and intracellular membranes. The activity of these proteins is regulated by a number of feedback mechanisms that act through the calmodulin-calcineurin pathway. When exposed to hypotonic shock (HTS), yeast cells respond with an increased cytosolic calcium transient, which seems to be conditioned by the opening of stretch-activated channels. To better understand the role of each channel and transporter involved in the generation and recovery of the calcium transient-and of their feedback regulations-we defined and analyzed a mathematical model of the calcium signaling response to HTS in yeast cells. The

SUBMITTER: Spolaor S 

PROVIDER: S-EPMC9158465 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature