Long-Term Stability of Blood Serum Biomarkers in Traumatic Brain Injury: A Feasibility Study.

ABSTRACT: Few studies on traumatic brain injury (TBI) have investigated the stability of blood serum biomarkers after long-term storage at low temperatures. In the current feasibility study we analyzed acute phase serum samples from patients with mild TBI as well as patients with moderate and severe TBI that were collected more than 10 years ago (old samples). We were particularly interested in mild TBI, because injury effects are more subtle in this category as compared to moderate-severe TBI. Therefore, the primary objective was to find out whether several biomarkers were still detectable for these patients. Additionally, we examined whether biomarker levels varied as a function of injury severity. For comparison, we also analyzed samples from an ongoing mTBI cohort (new samples) and

SUBMITTER: van der Horn HJ 

PROVIDER: S-EPMC9158477 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature