Metabolomic Profiles and Heart Failure Risk in Black Adults: Insights From the Jackson Heart Study.

ABSTRACT:

Background

Heart failure (HF) is a heterogeneous disease characterized by significant metabolic disturbances; however, the breadth of metabolic dysfunction before the onset of overt disease is not well understood. The purpose of this study was to determine the association of circulating metabolites with incident HF to uncover novel metabolic pathways to disease.

Methods

We performed targeted plasma metabolomic profiling in a deeply phenotyped group of Black adults from the JHS (Jackson Heart Study; n=2199). We related metabolites associated with incident HF to established etiological mechanisms, including increased left ventricular mass index and incident coronary heart disease. Furthermore, we evaluated differential associations of metabolites with HF with preserved ejectio

SUBMITTER: Tahir UA 

PROVIDER: S-EPMC9158510 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature