Evaluation of a CD13 and Integrin α_vβ₃ Dual-Receptor Targeted Tracer ⁶⁸Ga-NGR-RGD for Ovarian Tumor Imaging: Comparison With ¹⁸F-FDG.

ABSTRACT: Ovarian cancer has the highest mortality rate of gynecologic malignancy. ¹⁸F-FDG positron emission tomography (PET) adds an important superiority over traditional anatomic imaging modalities in oncological imaging but has drawbacks including false negative results at the early stage of ovarian cancer, and false positives when inflammatory comorbidities are present. Aminopeptidase N (APN, also known as CD13) and integrin α_vβ₃ are two important targets overexpressed on tumor neo-vessels and frequently on ovarian cancerous cells. In this study, we used subcutaneous and metastatic models of ovarian cancer and muscular inflammation models to identify ⁶⁸Ga-NGR-RGD, a heterodimeric tracer consisting of NGR and RGD peptides targeting CD13 and integrin α<

SUBMITTER: Long Y 

PROVIDER: S-EPMC9158524 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature