The deleterious effects of old social partners on Drosophila lifespan and stress resistance.

ABSTRACT: Social interactions play important roles in the modulation of behavior, physiology, and, potentially, lifespan. Although longevity has been studied extensively in different model organisms, due to the complexity of social environments, the social modulation of aging remains poorly investigated. The present study used the fruit fly, Drosophila melanogaster, as a model to study lifespan and stress resistance under different social conditions. Our experiments first showed that social isolation increased fly lifespan, suggesting a potential deleterious effect of social companions. Furthermore, we exposed flies to different aged social partners and found that living with old animals significantly reduced lifespan and stress resistance in young animals. In contrast, living with young animals inc

SUBMITTER: Lin YC 

PROVIDER: S-EPMC9158773 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature