Genetic associations with healthy ageing among Chinese adults.
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ABSTRACT:
SUBMITTER: Chang X
PROVIDER: S-EPMC9158790 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
Genetic associations with healthy ageing among Chinese adults.
Chang Xuling X Zhou Yan-Feng YF Wang Ling L Liu Jianjun J Yuan Jian-Min JM Khor Chiea-Chuen CC Heng Chew-Kiat CK Pan An A Koh Woon-Puay WP Dorajoo Rajkumar R
npj aging 20220502 1
The genetic basis of overall healthy ageing, especially among the East-Asian population is understudied. We conducted a genome-wide association study among 1618 Singapore Chinese elderly participants (65 years or older) ascertained to have aged healthily and compared their genome-wide genotypes to 6221 participants who did not age healthily, after a 20-year follow-up. Two genetic variants were identified (P<sub>Meta</sub> < 2.59 × 10<sup>-8</sup>) to be associated with healthy aging, including t ...[more]
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