The ESCRT-III machinery participates in the production of extracellular vesicles and protein export during Plasmodium falciparum infection.

ABSTRACT: Infection with Plasmodium falciparum enhances extracellular vesicle (EV) production in parasitized red blood cells (pRBCs), an important mechanism for parasite-to-parasite communication during the asexual intraerythrocytic life cycle. The endosomal sorting complex required for transport (ESCRT), and in particular the ESCRT-III sub-complex, participates in the formation of EVs in higher eukaryotes. However, RBCs have lost the majority of their organelles through the maturation process, including an important reduction in their vesicular network. Therefore, the mechanism of EV production in P. falciparum-infected RBCs remains to be elucidated. Here we demonstrate that P. falciparum possesses a functional ESCRT-III machinery activated by an alternative recruitment pathway involving the action

SUBMITTER: Avalos-Padilla Y 

PROVIDER: S-EPMC9159051 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature