Anticoagulation Control in Older Atrial Fibrillation Patients Receiving Vitamin K Antagonist Therapy for Stroke Prevention.

ABSTRACT:

Introduction

Efficacy and safety of vitamin K antagonists (VKAs) among atrial fibrillation (AF) patients are enhanced when the International Normalised Ratio (INR) is 2.0-3.0. Anticoagulation control among older patients is perceived to be lower and contributes to poorer initiation and uptake.

Objective

To examine the quality of INR control, adverse clinical outcomes, and factors associated with bleeding in older AF patients (≥80 years).

Methods

Anticoagulation control assessed by time in therapeutic range (TTR) (Rosendaal method) and percentage INRs in range (PINRR). Among the 205 patients aged ≥80 years, 58.5% were female, with mean (SD) CHA₂DS₂-VASc 4.4 (1.3) and HAS-BLED 1.8 (0.8) scores.

Results

Mean (SD) TTR and PINRR were similar fo

SUBMITTER: Zulkifly H 

PROVIDER: S-EPMC9159113 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature