Association between Genetic Polymorphisms and Risk of Kidney Posttransplant Diabetes Mellitus: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objectives

The purpose of this study was to clarify the role of genetic factors on posttransplant diabetes mellitus (PTDM) risk.

Methods

Relevant publications were systematically retrieved from PubMed, EMBASE, and the Cochrane Library up to December 2020. Data from eligible case-control and cohort studies were extracted for qualitative and quantitative analyses. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association between gene polymorphisms and PTDM in the quantitative meta-analysis.

Results

A total of 43 eligible articles were identified, and 16 studies on 9 DNA variants from 8 genes were included in the meta-analysis. TCF7L2 rs7903146 was significantly associated with PTDM risk in 5 genetic models (OR (95% CI): allelic: 1

SUBMITTER: Xu S 

PROVIDER: S-EPMC9159121 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature