Brain glycogen content is increased in the acute and interictal chronic stages of the mouse pilocarpine model of epilepsy.

ABSTRACT: Glucose is the main brain fuel in fed conditions, while astrocytic glycogen is used as supplemental fuel when the brain is stimulated. Brain glycogen levels are decreased shortly after induced seizures in rodents, but little is known about how glycogen levels are affected interictally in chronic models of epilepsy. Reduced glutamine synthetase activity has been suggested to lead to increased brain glycogen levels in humans with chronic epilepsy. Here, we used the mouse pilocarpine model of epilepsy to investigate whether brain glycogen levels are altered, both acutely and in the chronic stage of the model. One day after pilocarpine-induced convulsive status epilepticus (CSE), glycogen levels were higher in the hippocampal formation, cerebral cortex, and cerebellum. Opposite to expected, th

SUBMITTER: Seo GY 

PROVIDER: S-EPMC9159246 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature