Glymphatic system dysfunction in temporal lobe epilepsy patients with hippocampal sclerosis.

ABSTRACT:

Objective

This study aimed to evaluate glymphatic system function in temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (HS) in comparison to healthy controls, using diffusion tensor imaging (DTI)-analysis along the perivascular space (ALPS) method. We hypothesized that there is glymphatic system dysfunction in TLE patients with HS.

Methods

We retrospectively enrolled 25 TLE patients with HS and 26 age- and sex-matched healthy controls. All participants underwent DTI with the same 3T magnetic resonance imaging scanner, and the DTI-ALPS index was calculated. We evaluated the differences in the DTI-ALPS index between TLE patients with HS and healthy controls. Moreover, we evaluated the correlation between the DTI-ALPS index and clinical characteristics of epileps

SUBMITTER: Lee DA 

PROVIDER: S-EPMC9159256 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature