Xia2.multiplex: a multi-crystal data-analysis pipeline.

ABSTRACT: In macromolecular crystallography, radiation damage limits the amount of data that can be collected from a single crystal. It is often necessary to merge data sets from multiple crystals; for example, small-wedge data collections from micro-crystals, in situ room-temperature data collections and data collection from membrane proteins in lipidic mesophases. Whilst the indexing and integration of individual data sets may be relatively straightforward with existing software, merging multiple data sets from small wedges presents new challenges. The identification of a consensus symmetry can be problematic, particularly in the presence of a potential indexing ambiguity. Furthermore, the presence of non-isomorphous or poor-quality data sets may reduce the overall quality of the final merged data

SUBMITTER: Gildea RJ 

PROVIDER: S-EPMC9159281 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature