Dataset Information

Liquid biopsy in gliomas: A RANO review and proposals for clinical applications.

ABSTRACT:

Background

There is an extensive literature highlighting the utility of blood-based liquid biopsies in several extracranial tumors for diagnosis and monitoring.

Methods

The RANO (Response Assessment in Neuro-Oncology) group developed a multidisciplinary international Task Force to review the English literature on liquid biopsy in gliomas focusing on the most frequently used techniques, that is circulating tumor DNA, circulating tumor cells, and extracellular vesicles in blood and CSF.

Results

ctDNA has a higher sensitivity and capacity to represent the spatial and temporal heterogeneity in comparison to circulating tumor cells. Exosomes have the advantages to cross an intact blood-brain barrier and carry also RNA, miRNA, and proteins. Several clinical applications of liquid biopsies are suggested: to establish a diagnosis when tissue is not available, monitor the residual disease after surgery, distinguish progression from pseudoprogression, and predict the outcome.

Conclusions

There is a need for standardization of biofluid collection, choice of an analyte, and detection strategies along with rigorous testing in future clinical trials to validate findings and enable entry into clinical practice.

SUBMITTER: Soffietti R

PROVIDER: S-EPMC9159432 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Liquid biopsy in gliomas: A RANO review and proposals for clinical applications.

Soffietti Riccardo R Bettegowda Chetan C Mellinghoff Ingo K IK Warren Katherine E KE Ahluwalia Manmeet S MS De Groot John F JF Galanis Evanthia E Gilbert Mark R MR Jaeckle Kurt A KA Le Rhun Emilie E Rudà Roberta R Seoane Joan J Thon Niklas N Umemura Yoshie Y Weller Michael M van den Bent Martin J MJ Vogelbaum Michael A MA Chang Susan M SM Wen Patrick Y PY

Neuro-oncology 20220601 6

<h4>Background</h4>There is an extensive literature highlighting the utility of blood-based liquid biopsies in several extracranial tumors for diagnosis and monitoring.<h4>Methods</h4>The RANO (Response Assessment in Neuro-Oncology) group developed a multidisciplinary international Task Force to review the English literature on liquid biopsy in gliomas focusing on the most frequently used techniques, that is circulating tumor DNA, circulating tumor cells, and extracellular vesicles in blood and ...[more]

PMID: 34999836

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Project description:Background and objectiveLung cancer remains the leading cause of cancer-related mortality and constitutes a significant societal burden. Recent advancements in targeted therapies and immunotherapy have considerably broadened therapeutic options in lung cancer, particularly in non-small-cell lung cancer (NSCLC). However, these novel methods necessitate sophisticated molecular diagnostics. Liquid biopsy, which refers to the cytological and molecular analysis of cancer markers shed by the tumor into the body fluids, may offer an attractive diagnostic tool at the individual patient level. This approach is particularly relevant for lung cancer, as the anatomical location of tumor lesions frequently makes them inaccessible for tissue biopsy. Apart from minimal invasiveness, the major advantages of liquid biopsy include better reflection of the tumor clonal heterogeneity (spatial heterogeneity), the possibility of sequential sampling, and real-time monitoring of tumor load and its evolving mutational status (temporal heterogeneity).MethodsThis article reviews the available data in this field, current applications, and future perspectives in accordance with the Narrative Review reporting rules.Key content and findingsWe discuss the most used approaches, i.e., circulating DNA and tumor cells, but also emerging liquid biopsy techniques, such as plasma DNA methylation, plasma metabolites and RNA, extracellular vesicles, and tumor-educated platelets in NSCLC. Finally, we highlight the current limitations of liquid biopsy techniques hampering their clinical applications.ConclusionsDue to their advantages, liquid biopsy-based approaches have recently gained immense interest in oncology. Potential applications of this method include early detection, informing precision medicine-based individualized treatment, and real-time monitoring of disease evolution and treatment. The development of next-generation sequencing has vastly extended genetic profiling, thus enabling better identification of druggable alterations. However, the clinical application of liquid biopsy techniques is still limited due to their suboptimal specificity and sensitivity, lack of standardization, and relatively high costs. Addressing these issues may allow further integration of liquid biopsies in the routine clinical setting, thus making a profound and permanent change in NSCLC management.

Dataset Information

Liquid biopsy in gliomas: A RANO review and proposals for clinical applications.

Background

Methods

Results

Conclusions

Publications

Liquid biopsy in gliomas: A RANO review and proposals for clinical applications.

Similar Datasets

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