Liquid biopsy in gliomas: A RANO review and proposals for clinical applications.

ABSTRACT:

Background

There is an extensive literature highlighting the utility of blood-based liquid biopsies in several extracranial tumors for diagnosis and monitoring.

Methods

The RANO (Response Assessment in Neuro-Oncology) group developed a multidisciplinary international Task Force to review the English literature on liquid biopsy in gliomas focusing on the most frequently used techniques, that is circulating tumor DNA, circulating tumor cells, and extracellular vesicles in blood and CSF.

Results

ctDNA has a higher sensitivity and capacity to represent the spatial and temporal heterogeneity in comparison to circulating tumor cells. Exosomes have the advantages to cross an intact blood-brain barrier and carry also RNA, miRNA, and proteins. Several clinical applications of

SUBMITTER: Soffietti R 

PROVIDER: S-EPMC9159432 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature