Moving Beyond the Standard of Care: Accelerate Testing of Radiation-Drug Combinations.

ABSTRACT: Radiation therapy is a major treatment modality used in > 60% of cancer patients as definitive local treatment for inoperable locoregionally confined tumors and as palliative therapy. Although cytotoxic chemotherapy enhances the effectiveness of treatment, the benefit over radiation therapy alone is modest. There is a need to enhance the effectiveness of local tumor control over what sequentially or concurrently administered cytotoxic chemotherapy provides. Although many biological pathways are known to enhance the effectiveness of radiation therapy, there is currently a paucity of drugs approved for use in combination. Several clinical trials have tested the effectiveness of combining targeted agents or immunotherapies with radiation therapy, but the results of these trials have been nega

SUBMITTER: Lin SH 

PROVIDER: S-EPMC9159468 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature