Methodology-Centered Review of Molecular Modeling, Simulation, and Prediction of SARS-CoV-2.

ABSTRACT: Despite tremendous efforts in the past two years, our understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), virus-host interactions, immune response, virulence, transmission, and evolution is still very limited. This limitation calls for further in-depth investigation. Computational studies have become an indispensable component in combating coronavirus disease 2019 (COVID-19) due to their low cost, their efficiency, and the fact that they are free from safety and ethical constraints. Additionally, the mechanism that governs the global evolution and transmission of SARS-CoV-2 cannot be revealed from individual experiments and was discovered by integrating genotyping of massive viral sequences, biophysical modeling of protein-protein interactions, deep mutational da

SUBMITTER: Gao K 

PROVIDER: S-EPMC9159519 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature