Modification of associations between indoor particulate matter and systemic inflammation in individuals with COPD.

ABSTRACT:

Rationale

Little is known about personal characteristics and systemic responses to particulate pollution in patients with COPD.

Objectives

Assess whether diabetes, obesity, statins and non-steroidal anti-inflammatory medications (NSAIDs) modify associations between indoor black carbon (BC) and fine particulate matter ≤2.5 μm in diameter (PM_2.5) on systemic inflammation and endothelial activation.

Methods

144 individuals with COPD without current smoking and without major in-home combustion sources were recruited at Veterans Affairs Boston Healthcare System. PM_2.5 and BC were measured in each participant's home seasonally for a week (up to 4 times; 482 observations) and plasma biomarkers of systemic inflammation [C-reactive protein (CRP); interleu

SUBMITTER: Busenkell E 

PROVIDER: S-EPMC9159533 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature