Seroprevalence of hepatitis E virus infection in the Americas: Estimates from a systematic review and meta-analysis.

ABSTRACT:

Background

Hepatitis E virus (HEV) infection is responsible for inflammatory liver disease and can cause severe health problems. Because the seroprevalence of HEV varies within different population groups and between regions of the continent, we conducted a systematic review on the topic in order to provide evidence for targeted prevention strategies.

Methods

We performed a systematic review in PubMed, SCIELO, LILACS, EBSCO, and Cochrane Library and included reports up to 25 May 2021 (PROSPERO registration number: CRD42020173934). We assessed the risk of bias, publication bias, and heterogeneity between studies and conducted a random-effect meta-analysis for proportions using a (binomial-normal) generalized linear mixed model (GLMM) fitted by Maximum Likelihood (ML). We also

SUBMITTER: Fernandez Villalobos NV 

PROVIDER: S-EPMC9159553 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature