Association of Epigenetic Age Acceleration With Incident Mild Cognitive Impairment and Dementia Among Older Women.

ABSTRACT:

Background

Epigenetic age acceleration (AgeAccel), which indicates faster biological aging relative to chronological age, has been associated with lower cognitive function. However, the association of AgeAccel with mild cognitive impairment (MCI) or dementia is not well-understood. We examined associations of 4 AgeAccel measures with incident MCI and dementia.

Methods

This prospective analysis included 578 older women from the Women's Health Initiative Memory Study selected for a case-cohort study of coronary heart disease (CHD). Women were free of CHD and cognitive impairment at baseline. Associations of AgeAccel measures (intrinsic AgeAccel [IEAA], extrinsic AgeAccel [EEAA], AgeAccelPheno, and AgeAccelGrim) with risks for incident adjudicated diagnoses of MCI and dementia

SUBMITTER: Shadyab AH 

PROVIDER: S-EPMC9159659 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature