Cognitive impairment and microvascular function in end-stage renal disease.

ABSTRACT:

Objective

Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels.

Methods

152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions.

Results

SUBMITTER: Angermann S 

PROVIDER: S-EPMC9159686 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature