Using positional information to provide context for biological image analysis with MorphoGraphX 2.0.

ABSTRACT: Positional information is a central concept in developmental biology. In developing organs, positional information can be idealized as a local coordinate system that arises from morphogen gradients controlled by organizers at key locations. This offers a plausible mechanism for the integration of the molecular networks operating in individual cells into the spatially coordinated multicellular responses necessary for the organization of emergent forms. Understanding how positional cues guide morphogenesis requires the quantification of gene expression and growth dynamics in the context of their underlying coordinate systems. Here, we present recent advances in the MorphoGraphX software (Barbier de Reuille et al., 2015⁠) that implement a generalized framework to annotate developing organs wi

SUBMITTER: Strauss S 

PROVIDER: S-EPMC9159754 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature