Identification of shared and disease-specific host gene-microbiome associations across human diseases using multi-omic integration.

ABSTRACT: While gut microbiome and host gene regulation independently contribute to gastrointestinal disorders, it is unclear how the two may interact to influence host pathophysiology. Here we developed a machine learning-based framework to jointly analyse paired host transcriptomic (n = 208) and gut microbiome (n = 208) profiles from colonic mucosal samples of patients with colorectal cancer, inflammatory bowel disease and irritable bowel syndrome. We identified associations between gut microbes and host genes that depict shared as well as disease-specific patterns. We found that a common set of host genes and pathways implicated in gastrointestinal inflammation, gut barrier protection and energy metabolism are associated with disease-specific gut microbes. Additionally, we also found that mucosal

SUBMITTER: Priya S 

PROVIDER: S-EPMC9159953 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature