Norcantharidin ameliorates the development of murine lupus via inhibiting the generation of IL-17 producing cells.

ABSTRACT: Systemic lupus erythematosus (SLE) is a devastating autoimmune disorder associated with severe organ damage. The abnormality of T cell apoptosis is considered as an important pathogenetic mechanism of SLE. Norcantharidin (NCTD), a derivative of Cantharidin, is an efficacious anti-cancer drug by inhibiting cell proliferation and inducing cell apoptosis. Besides, NCTD has also been proved to protect the function of kidneys, while damaged renal function is the most important predictor of morbidity and mortality in SLE. All these suggest the potential effects of NCTD in SLE treatment. In this study we investigated whether NCTD exerted therapeutic effects in a mouse SLE model. Lupus prone female MRL/lpr mice were treated with NCTD (1, 2 mg·kg^-1·d^-1, ip) for 8 weeks. We sho

SUBMITTER: Du LJ 

PROVIDER: S-EPMC9159996 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature