Plasma acylcarnitines and risk of incident heart failure and atrial fibrillation: the Prevencion con dieta mediterranea study.

ABSTRACT:

Introduction and objectives

Fatty acid metabolic dysregulation in mitochondria is a common mechanism involved in the development of heart failure (HF) and atrial fibrillation (AF). We evaluated the association between plasma acylcarnitine levels and the incidence of HF or AF, and whether the mediterranean diet (MedDiet) may attenuate the association between acylcarnitines and HF or AF risk.

Methods

Two case-control studies nested within the Prevención con dieta mediterránea (PREDIMED) trial. High cardiovascular risk participants were recruited in Spain: 326 incident HF and 509 AF cases individually matched to 1 to 3 controls. Plasma acylcarnitines were measured with high-throughput liquid chromatography-tandem mass spectrometry. Conditional logistic regression models were fi

SUBMITTER: Ruiz-Canela M 

PROVIDER: S-EPMC9160218 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature