Association of stress-related disorders with subsequent risk of all-cause and cause-specific mortality: A population-based and sibling-controlled cohort study.

ABSTRACT:

Background

Prior research provides suggestive evidence on an association between stress-related disorders and mortality. No previous study has however addressed the role of familial confounding on such association.

Methods

We conducted a nationwide cohort study of 189,757 individuals with a first-onset stress-related disorder between January 1, 1981 and December 31, 2016 in Sweden (i.e., exposed patients), 1,896,352 matched unexposed individuals, and 207,479 unaffected full siblings of the exposed patients. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of all-cause and cause-specific mortality.

Findings

During a mean follow-up of 9.42 years, an elevated risk of all-cause mortality was observed during t

SUBMITTER: Tian F 

PROVIDER: S-EPMC9160321 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature