Ex-vivo lung perfusion therapies: do they add value to organ donation?

ABSTRACT:

Purpose of review

Significant limitations in organ availability and postoperative graft dysfunction plague lung transplantation and there is continual need for innovation. Ex-vivo lung perfusion (EVLP) has emerged over the last decade as an alternative and/or complementary allograft storage and assessment tool, however logistical hurdles have limited its widespread dissemination. As such, the overall current and potential value of EVLP on modern-day lung transplantation should be considered as innovation moves forward.

Recent findings

Since inception, EVLP has made important safety strides in conclusively showing noninferiority to cold storage in several trials. Recent advances have highlighted potential mechanisms by which EVLP in its current form may reduce the pathogenic

SUBMITTER: Lyengar A 

PROVIDER: S-EPMC9160442 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature