Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic-ischemic white matter damage.

ABSTRACT:

Aim

White matter damage (WMD) is the main cause of cerebral palsy and cognitive impairment in premature infants. Although caffeine has been shown to possess neuroprotective effects in neonatal rats with hypoxic-ischemic WMD, the mechanisms underlying these protective effects are unclear. Herein, proteins modulated by caffeine in neonatal rats with hypoxic-ischemic WMD were evaluated.

Methods

We identified differential proteins and performed functional enrichment analyses between the Sham, hypoxic-ischemic WMD (HI), and HI+caffeine-treated WMD (Caffeine) groups. Confirmed the changes and effect of proteins in animal models and determined cognitive impairment via water maze experiments.

Results

In paraventricular tissue, 47 differential proteins were identified between

SUBMITTER: Yang L 

PROVIDER: S-EPMC9160447 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature