Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization.

ABSTRACT:

Background

Inflammatory reactions induced by spinal cord injury (SCI) are essential for recovery after SCI. Atractylenolide III (ATL-III) is a natural monomeric herbal bioactive compound that is mainly derived in Atractylodes macrocephala Koidz and has anti-inflammatory and neuroprotective effects.

Objective

Here, we speculated that ATL-III may ameliorate SCI by modulating microglial/macrophage polarization. In the present research, we focused on investigating the role of ATL-III on SCI in rats and explored the potential mechanism.

Methods

The protective and anti-inflammatory effects of ATL-III on neuronal cells were examined in a rat SCI model and lipopolysaccharide (LPS)-stimulated BV2 microglial line. The spinal cord lesion area, myelin integrity, and surviving neu

SUBMITTER: Xue MT 

PROVIDER: S-EPMC9160450 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature