The attenuation effect of potassium 2-(1-hydroxypentyl)-benzoate in a mouse model of diabetes-associated cognitive decline: The protein expression in the brain.

ABSTRACT:

Aims

dl-PHPB (potassium 2-(1-hydroxypentyl)-benzoate) has been shown to have neuroprotective effects against acute cerebral ischemia, vascular dementia, and Alzheimer's disease. The aim of this study was to investigate the effects of dl-PHPB on memory deficits and preliminarily explore the underlying molecular mechanism.

Methods

Blood glucose and behavioral performance were evaluated in the KK-A^y diabetic mouse model before and after dl-PHPB administration. Two-dimensional difference gel electrophoresis (2D-DIGE)-based proteomics was used to identify differentially expressed proteins in brain tissue. Western blotting was used to study the molecular mechanism of the related signaling pathways.

Results

Three-month-old KK-A^y mice were given 150 mg/k

SUBMITTER: Yu W 

PROVIDER: S-EPMC9160457 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature