Incidence rates of dilated cardiomyopathy in adult first-degree relatives versus matched controls.

ABSTRACT:

Background

The incidence rates and importance of traditional risk factors in dilated cardiomyopathy among first-degree relatives are unknown.

Methods and results

We identified all probands with dilated cardiomyopathy (n = 13,714, mean age at diagnosis 63 years) from the Danish nationwide registries between 1994 and 2017. Incidence rates among first-degree relatives (n = 29,671, mean age 38 years) and for up to 10 age- and sex-matched controls were calculated. Totally 233 (0.8%) first-degree relatives and 285 (0.1%) controls developed dilated cardiomyopathy during a median follow-up of 8.2 (Q1-Q3 4.4-13.3) years. Incidence rates (per 100,000 person-years) were 86.4 (95% confidence interval 73.9-101.0) and 111.1 (79.4-128.7) for first-degree relatives aged < 50 and ≥ 50 years,

SUBMITTER: Andersson C 

PROVIDER: S-EPMC9160477 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature