Machine Learning-Assisted Screening of Herbal Medicine Extracts as Vaccine Adjuvants.

ABSTRACT: Adjuvants are important vaccine components, composed of a variety of chemical and biological materials that enhance the vaccine antigen-specific immune responses by stimulating the innate immune cells in both direct and indirect manners to produce a variety cytokines, chemokines, and growth factors. It has been developed by empirical methods for decades and considered difficult to choose a single screening method for an ideal vaccine adjuvant, due to their diverse biochemical characteristics, complex mechanisms of, and species specificity for their adjuvanticity. We therefore established a robust adjuvant screening strategy by combining multiparametric analysis of adjuvanticity in vivo and immunological profiles in vitro (such as cytokines, chemokines, and growth factor secre

SUBMITTER: Hioki K 

PROVIDER: S-EPMC9160479 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature