Autophagy Impairment in App Knock-in Alzheimer's Model Mice.

ABSTRACT: Alzheimer's disease (AD) is characterized by impaired protein homeostasis leading to amyloid-β peptide (Aβ) amyloidosis. Amyloid precursor protein (APP) knock-in mice exhibit robust Aβ pathology, providing possibilities to determine its effect on protein homeostasis including autophagy. Here we compared human AD postmortem brain tissue with brains from two different types of App knock-in mice, App ^NL-F and App ^NL-G-F mice, exhibiting AD-like pathology. In AD postmortem brains, p62 levels are increased and p62-positive staining is detected in neurons, including potential axonal beadings, as well as in the vasculature and in corpora amylacea. Interestingly, p62 is also increased in the neurons in 12-month-old Ap

SUBMITTER: Jiang R 

PROVIDER: S-EPMC9160569 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature