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Synthesis and Bioactivities of Novel Galactoside Derivatives Containing 1,3,4-Thiadiazole Moiety.

ABSTRACT: A series of novel galactoside derivatives containing 1,3,4-thiadiazole moiety were synthesized, and the structure of them was verified by spectroscopy of NMR and HRMS, and antifungal and antibacterial activities of them were screened. The results showed that the newly synthesized compounds had good antifungal activities. Among them, Ⅲ16, Ⅲ17, and Ⅲ19 exhibited satisfactory activities against Phytophthora infestans (P. infestans), with EC₅₀ values of 5.87, 4.98, and 6.17 μg/ml, respectively, which were similar to those of dimethomorph (5.52 μg/ml). Meanwhile, the title compounds also possessed certain antibacterial activities.

SUBMITTER: Shu Y

PROVIDER: S-EPMC9160659 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Synthesis and Bioactivities of Novel Galactoside Derivatives Containing 1,3,4-Thiadiazole Moiety.

Shu Yafei Y Chen Meihang M Lu Daowang D Zhou Zengyan Z Yu Jianhong J Hu Xiaoling X Yang Jiaqin J Li Aiqin A Liu Jianglong J Luo Hairong H

Frontiers in chemistry 20220519

A series of novel galactoside derivatives containing 1,3,4-thiadiazole moiety were synthesized, and the structure of them was verified by spectroscopy of NMR and HRMS, and antifungal and antibacterial activities of them were screened. The results showed that the newly synthesized compounds had good antifungal activities. Among them, Ⅲ16, Ⅲ17, and Ⅲ19 exhibited satisfactory activities against <i>Phytophthora infestans (P. infestans)</i>, with EC<sub>50</sub> values of 5.87, 4.98, and 6.17 μg/ml, ...[more]

PMID: 35665058

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