Diabetes impairs fracture healing through disruption of cilia formation in osteoblasts.

ABSTRACT: Diabetes-associated fracture risk and impaired fracture healing represents a serious health threat. It is well known that type 1 diabetes mellitus (T1DM) impairs fracture healing due to its effect on osteoblasts and their progenitor cells. Previous studies have showed that primary cilia and intraflagellar transport protein 80 (IFT80) are critical for bone formation. However, whether TIDM impairs fracture healing due to influencing ciliary gene expression and cilia formation is unknown. Here, we investigated the effect of T1DM on primary cilia in a streptozotocin induced diabetes mouse model and examined the impact of cilia on fracture healing in osteoblasts by deletion of IFT80 in osteoblast linage using osterix (OSX)-cre (OSX^cretTAIFT80^f/f). The results showed that d

SUBMITTER: Chinipardaz Z 

PROVIDER: S-EPMC9160738 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature