Computing R ₀ of dynamic models by a definition-based method.

ABSTRACT:

Objectives

Computing the basic reproduction number (R ₀) in deterministic dynamical models is a hot topic and is frequently demanded by researchers in public health. The next-generation methods (NGM) are widely used for such computation, however, the results of NGM are usually not to be the true R ₀ but only a threshold quantity with little interpretation. In this paper, a definition-based method (DBM) is proposed to solve such a problem.

Methods

Start with the definition of R ₀, consider different states that one infected individual may develop into, and take expectations. A comparison with NGM has proceeded. Numerical verification is performed using parameters fitted by data of COVID-19 in Hunan Province.

Results

SUBMITTER: Guo X 

PROVIDER: S-EPMC9160772 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature