Plasma p-tau₁₈₁ shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau.

ABSTRACT:

Introduction

We examined the ability of plasma hyperphosphorylated tau (p-tau)₁₈₁ to detect cognitive impairment due to Alzheimer's disease (AD) independently and in combination with plasma total tau (t-tau) and neurofilament light (NfL).

Methods

Plasma samples were analyzed using the Simoa platform for 235 participants with normal cognition (NC), 181 with mild cognitive impairment due to AD (MCI), and 153 with AD dementia. Statistical approaches included multinomial regression and Gaussian graphical models (GGMs) to assess a network of plasma biomarkers, neuropsychological tests, and demographic variables.

Results

Plasma p-tau₁₈₁ discriminated AD dementia from NC, but not MCI, and correlated with dementia severity and worse neuropsychological te

SUBMITTER: Frank B 

PROVIDER: S-EPMC9160800 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature